Like everything great it appears superficially as a paradox, but there’s now a practical model for it:
The paradox Burt had to solve is how something very bad for mosquitoes could also be spread by them. One answer, he saw, was a selfish gene that is harmless if one copy is present but causes sterility if two copies are. (Like humans, mosquitoes have two sets of chromosomes, one from each parent.) Starting with a male mosquito with one copy, the selfish gene will ensure that it ends up in every one of his sperm, rather than just half. That way any offspring with a wild mosquito will also be carriers, as will all their offspring’s offspring. As a result, the gene will rocket through the population. […] Eventually, it becomes likely that any mating pair of mosquitoes will both be carriers — and their offspring, with two copies, will be infertile. Quickly, the population will crash, reeling from the genetic poison.
So the provocation of malaria has resulted in a remarkable piece of abstract anti-biological ordnance being put together. (Abstract, because the principles are applicable to any sexually reproducing species. The concrete details of the mosquito-killing version are fascinating, and outlined in the article.)
Hypothetically, the optimum strategic environment in which to unleash this thing is high-intensity global warfare between bio-conservatives and their enemies. Given the length of the human generational cycle, it would be a slow weapon — but one that compelled its target population to submit to techno-genetic plasticization as the only alternative to extinction. Naturally, all vestiges of decency would have had to be stripped from the conflict for such abominable genius to be imaginable (which is why it’s a Frightday night scenario here at XS, where we’re appalled, of course). In any case, the essential asymmetry of this thing in the direction of extreme neo-eugenics is unmistakable, once noticed.
Technology is neutral goes the orthogonalist refrain. Really, it isn’t.